Open problem OP-01
Trustworthy bench measurements
Which measurement limitations could invalidate an interpretation of the first Neuroclearance bench results?
First useful contribution: A proposed calibration, timing and uncertainty plan for the bench configuration, written against the stated conditions.
Expertise: Instrumentation, metrology, controls engineering
Status: Open now · contact David Sherrer · updated September 28, 2026
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Open problem OP-02
Evidence for lasting benefit
What would distinguish a transient physiological response from meaningful, durable function in brain-health research?
First useful contribution: An endpoint and alternative-explanations review: what would count, what could mislead, and what a later study would need.
Expertise: Neuroscience, physiology, clinical methods, statistics
Status: Open now · contact David Sherrer · updated September 28, 2026
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Open problem OP-03
Memory that can be checked
How can a research system retain why a decision was made and revise that record correctly when new evidence arrives?
First useful contribution: A small evaluation set: questions, the sources that answer them, and decision revisions a system should reproduce.
Expertise: Knowledge representation, retrieval, scientific software
Status: Open now · contact David Sherrer · updated September 28, 2026
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Open problem OP-04
Model to physical evidence
How should measured results change a model and the next experiment, in a way a later engineer can audit?
First useful contribution: A reproducible example with model assumptions, a measurement, comparison criteria and the resulting revision.
Expertise: Applied mathematics, physics, experimental design
Status: Open now · contact David Sherrer · updated September 28, 2026
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