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Open problems

Hard questions, waiting for the right minds.

Each brief is a real question from the work, with what we know, what we do not, and one contribution that would move it forward. Pick the one that excites you and tell us what you would bring.

Open collaboration. Scope, time, access and compensation are agreed before work begins.

Four briefs

Open now · updated September 28, 2026

Open problem OP-01

Trustworthy bench measurements

Which measurement limitations could invalidate an interpretation of the first Neuroclearance bench results?

First useful contribution: A proposed calibration, timing and uncertainty plan for the bench configuration, written against the stated conditions.

Expertise: Instrumentation, metrology, controls engineering
Status: Open now · contact David Sherrer · updated September 28, 2026

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Open problem OP-02

Evidence for lasting benefit

What would distinguish a transient physiological response from meaningful, durable function in brain-health research?

First useful contribution: An endpoint and alternative-explanations review: what would count, what could mislead, and what a later study would need.

Expertise: Neuroscience, physiology, clinical methods, statistics
Status: Open now · contact David Sherrer · updated September 28, 2026

Read the brief

Open problem OP-03

Memory that can be checked

How can a research system retain why a decision was made and revise that record correctly when new evidence arrives?

First useful contribution: A small evaluation set: questions, the sources that answer them, and decision revisions a system should reproduce.

Expertise: Knowledge representation, retrieval, scientific software
Status: Open now · contact David Sherrer · updated September 28, 2026

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Open problem OP-04

Model to physical evidence

How should measured results change a model and the next experiment, in a way a later engineer can audit?

First useful contribution: A reproducible example with model assumptions, a measurement, comparison criteria and the resulting revision.

Expertise: Applied mathematics, physics, experimental design
Status: Open now · contact David Sherrer · updated September 28, 2026

Read the brief

How it works

How a brief becomes a collaboration

  1. Read the brief and decide whether the first contribution is something you could do well.
  2. Send a short, non-confidential introduction through the form, with the problem preselected.
  3. David reviews it. If there is a useful next conversation, he replies to arrange scope, format and access.
  4. Scope, time and compensation are agreed before work begins. We never ask for unpaid proprietary work.

Owner for all briefs: David Sherrer. Briefs are reviewed monthly and after material milestones; the update date is shown on each page.